Myeloproliferative Neoplasms

Myeloproliferative neoplasms are a type of blood cancer that includes myelofibrosis, polycythemia vera and essential thrombocythemia.

Myeloproliferative neoplasms (MPNs) are types of blood cancer that begin with an abnormal mutation (change) in a stem cell in the bone marrow. The change leads to an overproduction of any combination of white cells, red cells and platelets.

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Types of MPNs

Essential Thrombocythemia

Essential Thrombocythemia (ET) Is a rare blood disease in which the bone marrow produces too many platelets. High numbers of platelets may lead to a thrombus, a blood clot that forms in a blood vessel. This can cause serious health problems such as a stroke, heart attack or pulmonary embolism Is one of a related group of blood cancers known as “myeloproliferative neoplasms” (MPNs) in w...


Myelofibrosis (MF) Is a rare disorder in which abnormal blood cells and fibers build up in the bone marrow. Is one of a related group of blood cancers known as “myeloproliferative neoplasms (MPNs)” in which bone marrow cells that produce blood cells develop and function abnormally.    What You Should Know Hematologists oncologists are specialists who treat people who have myelofibr...

Polycythemia Vera

Polycythemia Vera (PV)     Is one of a related group of blood cancers known as “myeloproliferative neoplasms” (MPNs). Too many red blood cells are made in the bone marrow and, in many cases, the numbers of white blood cells and platelets are also elevated.  With careful medical supervision, PV can usually be managed effectively for many years. For some PV patients, however, the PV...